WebOct 31, 2024 · Inhibitors for BUB1 or PLK1, which are upstream of BUB1B in mitotic checkpoint pathway in addition to their other roles in mitosis, are either in development or early stages of clinical trials. BUB1 inhibitors show decreased proliferation of cancer cells and in vivo tumor growth both as a single agent and combined with paclitaxel [ 23 , 24 ]. Chemoradiotherapy (CRT), the combination of chemotherapy and radiotherapy applied with curative intent, is used to treat a variety of cancers. CRT acts by inducing damage in the DNA of the cancer cells. Bladder cancer tumor samples were taken from patients before treatment and from the same patients after CRT treatment when the tumors had reoccurred. An increased level of BUB1B expression was found in the CRT-recurrent cells. This increased expression was con…
Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes …
WebBUB1B; BUB1 mitotic checkpoint serine/threonine kinase B: Aliases: MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta : Location: ... CU-ACC1 and CU-ACC2, compared … WebApr 4, 2024 · Abstract 2477: Evaluating the effects of Bcl2 inhibitor, venetoclax, on cellular growth and clustering in triple-negative breast cancer cells April 2024 Cancer Research 83(7_Supplement):2477-2477 portillo nissan
Integrative analysis of key candidate genes and signaling pathways …
WebFeb 8, 2024 · Gong and colleagues carried out an shRNA loss-of-function screen to identify genes that rescue synthetic lethality between RB1 mutation and Aurora kinase A inhibitors. They identified mitotic checkpoint components BUB1B and BUB3 as essential for synthetic lethality, further underscoring the importance of a hyperactivated spindle assembly ... WebJun 16, 2024 · BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) gene belongs to the spindle assembly checkpoint protein family, proven to be associated with many … WebJan 11, 2024 · BUB1B regulated the proliferation and invasiveness of CAA cells in a JNK-c-Jun-dependent manner. ... Recent progress in the design, study, and development of c-Jun N-terminal kinase inhibitors as ... portillo joma