Dethiobiotin synthetase
Webdethiobiotin synthetase Synonyms: Evidence for Translation: Charge (pH 7)-7.44 Kyte-Doolittle Hydrophobicity Value: 0.323 Molecular Weight (kDa) 23.6 Isoelectric Point (pI) 5.02 Subcellular localization. Individual Mappings: Localization Confidence PMID; Cytoplasmic ... WebOct 15, 1998 · The crystal structure of the 224-residue protein dethiobiotin synthetase from Escherichia coli has been refined using X-ray diffraction data at 0.97 A resolution at 100 K. The model, consisting of 4143 protein atoms including 1859 H atoms and 436 solvent sites, was refined to a final R factor of 11 ... Macromolecules
Dethiobiotin synthetase
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WebSep 5, 1995 · The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to … WebSpecifically, DTBS allows for the ATP-dependent formation of dethiobiotin from 7,8-diaminopelargonic acid (DAPA) and CO 2 by catalyzing a ureido ring formation(4). The …
WebMay 8, 1995 · The crystal structures of six complexes of homodimeric Escherichia coli dethiobiotin synthetase with a variety of substrates, substrate analogs, and products … WebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details.
WebThis article is cited by 32 publications. Andrew P. Thompson, Wanisa Salaemae, Jordan L. Pederick, Andrew D. Abell, Grant W. Booker, John B. Bruning, Kate L. Wegener, Steven W. Polyak. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. WebApr 7, 2024 · Atlanta, city, capital (1868) of Georgia, U.S., and seat (1853) of Fulton county (but also partly in DeKalb county). It lies in the foothills of the Blue Ridge Mountains in …
WebApr 16, 2010 · Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi, and plants. As humans lack this pathway, DTBS is a promising antimicrobial drug target. We determined structures of DTBS from Helicobacter pylori (hpDTBS) bound with cofactors and a substrate analog, and described its unique characteristics relative to ...
WebJan 6, 2004 · The structure reveals a nearly symmetric 222 tetramer, in which each bifunctional monomer contains a dethiobiotin synthetase-like amidoligase N-terminal domain and a Type 1 glutamine amidotransferase C-terminal domain. For each amidoligase active site, essential ATP- and UTP-binding surfaces are contributed by three … how do i connect keyboard to lg smart tvWebD-Desthiobiotin. (Synonyms: Dethiobiotin) Cat. No.: HY-128699 Purity: 98.19%. COA Handling Instructions. D-Desthiobiotin is a biotin derivative used in affinity … how much is one fifth of alcoholWebSep 5, 1995 · Mechanism of an ATP-Dependent Carboxylase, Dethiobiotin Synthetase, Based on Crystallographic Studies of Complexes with Substrates and a Reaction Intermediate. Biochemistry 1995, 34 (35) , 10985-10995. how do i connect ipod to pcWebDethiobiotin synthetase, DTBS, (PDB id = 1a82) plays an important role in the biotin synthetic pathway. Better known as vitamin H, all organisms require biotin. Biotin’s necessity for life lies in its identity as a prosthetic group for the enzymes that catalyze the many biological carboxylation and transcarboxylation reactions (1). how much is one figure a yearWebApr 30, 2012 · The Two-Step Synthesis of DTB from KAPA. (A) In bacteria, DTB is synthesized from KAPA by two distinct enzymes encoded by bioA and bioD genes, respectively, catalyzing successively DAPA-AT and DTBS reactions. AdoMTOB, S -adenosyl-2-oxo-4-methylthiobutyric acid. how much is one fifth of vodkaWebSep 5, 1995 · Dethiobiotin synthetase (DTBS) catalyzes the penultimate step in biotin biosynthesis, the formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (7,8-diaminopelargonic acid, DAPA), CO2, and ATP. Solutions of DAPA at neutral pH readily formed a mixture of the N7- and N8-carbamates in the … how do i connect laptop to pchow much is one fl oz