Structural maintenance of chromosomes 4

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August undefined, 2024

WebStructural Maintenance of Chromosomes 2 (SMC2) and Structural Maintenance of Chromosomes 4 (SMC4) are the core components of the condensin complexes, which are required for chromosome assembly and faithful segregation during cell division. Because of the crucial functions of both proteins in cell division, much work has been done in various ... WebMar 26, 2024 · Smc4 structural maintenance of chromosomes 4 [ (house mouse)] Gene ID: 70099, updated on 26-Mar-2024. Summary. Enables chromatin binding activity and single …

Smc4 MGI Mouse Gene Detail - MGI:1917349 - structural maintenance …

Webcell survival [4], chromosome dynamics [5-7], cell cycle regulation[8, 9] and DNA damage repair [10-12]. Importantly, SMC1-mediated chromosome structure stability and DNA damage repair are considered as important mechanisms for the maintenance of genome integrity. Although there is increasing evidence that SMC1 is closely associated WebDec 8, 2024 · This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. ra 2501

SMC4 knockdown inhibits malignant biological behaviors of ... - PubMed

WebMar 25, 2003 · Structural maintenance of chromosomes protein 3. Short names. SMC protein 3; SMC-3. Alternative names. Basement membrane-associated chondroitin proteoglycan (Bamacan) Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide (hCAP) Gene names. Name. SMC3. Synonyms. BAM, BMH, CSPG6, SMC3L1. … WebMay 10, 2005 · Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. don\u0027t brag gif

Structural maintenance of chromosomes (SMC) proteins

SMC protein - Wikipedia

SMC complexes represent a large family of ATPases that participate in many aspects of higher-order chromosome organization and dynamics. SMC stands for Structural Maintenance of Chromosomes. WebFeb 11, 2014 · By PCR of human cDNA libraries using degenerate primers based on conserved C-terminal sequences of Xenopus, yeast, and C. elegans SMC proteins, … ra25WebNov 15, 2024 · DOI: 10.1016/j.abb.2024.109026 Abstract Structural maintenance of chromosomes 4 (SMC4) has an important role in chromosome condensation and segregation, which is involved in regulating multiple tumor development. However, the role of SMC4 in endometrial cancer is uncertain. don\\u0027t break down jawbreaker

"WebApr 14, 2016 · SMC (structural maintenance of chromosomes) complexes are found in all living organisms and include condensin, cohesin and the SMC5–SMC6 complex. Recent mechanistic insight into these ring ... " - Structural maintenance of chromosomes 4

Structural maintenance of chromosomes 4

WebCohesin is an evolutionarily conserved complex that belongs to the Structural Maintenance of Chromosomes (SMC; see Glossary) family. It comprises the heterodimer of SMC1 and SMC3, the kleisin subunit RAD21, and the HEAT-repeat subunit Stromal Antigen or SA/STAG (Figure 1A). Following the identification of cohesin in yeast, a separate heterodimer of … WebApr 12, 2024 · Notably, structural variants per megabase were particularly enriched on chromosome 11 compared to the rest of the genome (P value = 0.000015; Extended Data Fig. 15a), with chromosomes 3 and 11 ...

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WebMar 21, 2024 · SMC4 (Structural Maintenance Of Chromosomes 4) is a Protein Coding gene. Diseases associated with SMC4 include Pleural Empyema and Breast Cancer . … WebAug 5, 2024 · Introduction. Structural maintenance of chromosomes (SMC) proteins are ATPases that participate in maintaining the integrity of chromosome structure and have been found in all the domains of Life, indicating their significance for cellular viability (Losada and Hirano, 2005).The SMC proteins identified so far can be split into two …

WebSMC4 (structural maintenance of chromosomes 4) 2007-11-01 Affiliation Identity. HGNC. SMC4. LOCATION. 3q25.33. LOCUSID. 10051. ALIAS. CAP-C, CAPC, SMC-4, SMC4L1. … WebApr 4, 2024 · structural maintenance of chromosomes 4 Synonyms 2500002A22Rik, Smc4l1 Feature Type protein coding gene IDs MGI:1917349 NCBI Gene: 70099 Alliance gene page …

WebApr 4, 2024 · SMC4, structural maintenance of chromosomes 4 Vertebrate Orthologs 3 Human Diseases less References 1 with disease annotations Mutations, Alleles, and Phenotypes less Phenotype Summary 11 phenotype references All Mutations and Alleles 26 Chemically induced (other) 1 Endonuclease-mediated 1 Gene trapped 21 Radiation … WebMar 31, 2024 · Biochemical and genetic evidence with baker’s yeast suggest that the canonical cohesin complex contains two structural maintenance of chromosomes (SMC) proteins, SMC1 and SMC3; one α-kleisin subunit named SCC1/RAD21 (mitotic) or REC8/SYN1 (meiotic; Beckouët et al., 2016; Hsieh et al., 2024 ); and two additional HEAT …

WebFeb 15, 2000 · In somatic cells, the heterodimeric Structural Maintenance of Chromosomes (SMC) proteins are involved in chromosome condensation and gene dosage compensation (SMC2 and 4), and sister chromatid cohesion and DNA recombination (SMC1 and 3). We report here evidence for an involvement of mammalian SMC1 and SMC3 proteins in …

WebAug 22, 2014 · Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics and control... ra 2515WebStructural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is … ra 248WebJul 31, 2024 · B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be that they have … ra 2500WebDec 5, 2014 · Introduction. Members of the structural maintenance of chromosomes (SMC) 3 family of ATPases are conserved through evolution and play critical roles in chromosomal duplication and segregation (1, 2, 3).Different heterodimers of SMC proteins carry out distinct function. For example, the core of the cohesin complex consists of SMC1 and … ra 2489WebBackground: Structural maintenance of chromosomes 4 (SMC-4) is a chromosomal ATPase which plays an important role in regulate chromosome assembly and segregation. … ra 2514WebDec 25, 2001 · About five years ago, the term ‘SMC family’ was coined [], which stands for the ‘Structural Maintenance of Chromosomes’ family of genes and proteins [].Reflecting the recognition of a new type of protein, conserved from most prokaryotes to all eukaryotes examined, this term marks the beginning of a rapidly evolving analysis leading to fresh … don\u0027t break upWebFeb 5, 2024 · Title: Structural maintenance of chromosomes 4 is a predictor of survival and a novel therapeutic target in colorectal cancer. SMC4 expression was significantly … ra 252